Journal article
Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries
A Fu, SM Oberholtzer, S Bagheri-Fam, RH Rastetter, C Holdreith, VL Caceres, SV John, SA Shaw, KJ Krentz, X Zhang, CC Hui, D Wilhelm, JS Jorgensen
Plos Genetics | PUBLIC LIBRARY SCIENCE | Published : 2018
Abstract
Women and other mammalian females are born with a finite supply of oocytes that determine their reproductive lifespan. During fetal development, individual oocytes are enclosed by a protective layer of granulosa cells to form primordial follicles that will grow, mature, and eventually release the oocyte for potential fertilization. Despite the knowledge that follicles are dysfunctional and will die without granulosa cell-oocyte interactions, the mechanisms by which these cells establish communication is unknown. We previously identified that two members of the Iroquois homeobox transcription factor gene family, Irx3 and Irx5, are expressed within developing ovaries but not testes. Deletion o..
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Awarded by National Institutes of Health
Funding Acknowledgements
Funding sources include the National Institute of Health, The Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD075079 (JSJ); the University of Wisconsin Carbone Cancer Center Support Grant, National Institute of Health, National Cancer Institute P30 CA014520 (KJK, JSJ); the National Science Foundation-Research Experiences for Undergraduates NSF-REU 1659159 (SVJ); the National Institute of Health, Office of Research Infrastructure Programs, Short-term Research Training for Veterinary Students in Wisconsin, T35OD011078 (VLC); the Canadian Institute of Health Research Operating Grant (CCH); and the Endocrinology and Reproductive Physiology Program Research Supply Pilot Grants (AF, JSJ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.